WAM would not have been possible without extensive research into the structural detail of antibody complementarity-determining regions and into improving their modelling. On this section of the site various background topics on antibody structure and modelling are presented.
- Introduction - an introduction to antibody Fv structure and existing (pre-WAM) work on modelling.
- WAM canonical classes - the revised structural classification used in WAM for CDRs L1 to H2.
- Recent advances in CDR-H3 structural knowledge - many of the improvements in WAM compared to its predecessor, Oxford Molecular's AbM, result from a greater understanding of sequence/structure relationships in CDR-H3. This is discussed here. UPDATED!
- The WAM algorithm - an in-depth discussion of the algorithm used in WAM, including how it improves upon the original AbM algorithm.
- Sidechain modelling - a description of the two alternative methods for building CDR sidechains within WAM.
- Screens and sample results - a discussion of the various alternative screening methods for CDR-H3 models, along with an indication of their relative efficacy for various H3 loop lengths.
- Sequence / structure relationships in screening CDR-H3 by WAM - how some of the very latest developments in the CDR-H3 section above have influenced the screening stage in WAM. UPDATED!
Last updated 21/10/02