Introduction

At the antibody modelling group of the Centre for Protein Analysis and Design, led by Professor Tony Rees , we have had a long history of antibody modelling and humanisation research. Originally located at the University of Oxford, we moved to Bath around ten years ago, and subsequently to the CPAD at Swindon in late 2000. We have developed WAM (initially as its predecessor, Oxford Molecular's AbM), continously since 1989, when our first paper on the algorithm was published.

Credits

We would like to thank the following past members of the group and others for their contributions in coding and testing the modules which make up WAM:

• Andrew Martin ( Home page; Email)
• Jan Pedersen
• Stephen Searle
• Andrew Henry
• David Osguthorpe (for VFF) ( Email)
• Robert Bruccoleri and Martin Karplus (for CONGEN)

Main publications

The following are our recent publications on antibody modelling.

• Martin, A.C.R., Cheetham, J.C. and Rees, A.R. (1989) Modelling antibody hypervariable loops: a combined algorithm. Proc. Natl. Acad. Sci. USA, 86, 9268-9272.
• Rees, A.R., Martin, A.C.R., Webster, D., Cheetham, J.C. and Roberts, S. (1990) Antibody combining sites: prediction and design. Biophys J.. 57, A384.
• Martin, A.C.R., Cheetham, J.C. and Rees, A.R. (1991) Molecular modelling of antibody combining sites. Meth.Enz., 203, 121-153.
• Pedersen, J.T., Searle, S.M.J., Henry, A.H. and Rees, A.R. (1992) Antibody modelling: Beyond homology. Immunomethods ,1, 126-136.
• Rees, A.R., Searle, S.M.J., Henry, A.H., Pedersen, J.T. and Whitelegg, N.R.J. (1996) Antibody combining sites: structure and prediction. In Sternberg M.J.E. (ed.) Protein Structure Prediction (1st ed.), Oxford University Press, 141-172.
• Whitelegg, N.R.J. (1998) PhD Thesis, "Molecular Modelling of Antibody Combining Sites", University of Bath, UK.
• Whitelegg, N.R.J. and Rees, A.R (2000). WAM - an improved algorithm for modelling antibodies on the Web. Prot.Eng., 13, 819-824.

Last updated 22/11/01